Misoprostol for Cervical Priming on Non-Pregnant Uterus

Endometerial biopsy is often performed as outpatient procedure. Difficulty may be encountered in entering cervical os especially in nulliparous women. This may cause, complications, excessive pain and may even hinder performance of the procedure. The same problem may occur during hysteroscopy, dilatation & curettage, chromopertubation, IUCD insertion or fractional curettage. If cervical priming is done by some agent before the procedure, complications may be reduced. Most of the minor gynaecological procedures may be done as outpatient procedures, which may reduce anesthetic complications and decrease hospital stay and hence reduce the cost of the procedure. In addition, occasionally an endometrial biopsy cannot be easily obtained secondary to anatomic cervical stenosis, scarring, or atrophy. These are two areas of concern, and it would be beneficial to our patients if the biopsy could be less painful.